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Case Report
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| Neuromyelitis optica spectrum disorder presenting as Brown-Sequard syndrome | ||||||
| Abhinav Agrawal1, Dennis Lourdusamy1, Abhishek Agarwal2, Neil R. Holland3 | ||||||
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1Department of Internal Medicine, Monmouth Medical Center, Long Branch, New Jersey, USA.
2Department of Internal Medicine, Cooper University Hospital, Camden, New Jersey, USA. 3Section of Neurology, Monmouth Medical Center, Long Branch, New Jersey, USA. | ||||||
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| How to cite this article |
| Agrawal A, Lourdusamy D, Agarwal A, Holland NR. Neuromyelitis optica spectrum disorder presenting as Brown-Sequard syndrome. Edorium J Neurol 2015;2:1–4. |
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Abstract
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Introduction:
Brown - Sequard syndrome (BSS) presents with features of ipsilateral motor function loss and contralateral loss of pain and temperature. It is most commonly caused from trauma/stab injuries and is also known to be be caused by multiple sclerosis. Here, we are presenting a rare case of neuromyelitis optica spectrum disorder (NMOSD) presenting as Brown - Sequard syndrome.
Case Report: A 70-year-old female presented the emergency room with a 2–3 day history of abrupt onset weakness in her left leg. Magnetic resonance imaging (MRI) scan of the spine showed T2 hyperintense signal seen within the upper thoracic cord centered at T2–T5 level with mild expansion of the cord. A diagnosis of neuromyelitis optica (NMO) spectrum disorder was made based on positive AQP4 antibody titres. Conclusion: This case underscores the clinical diversity of NMO spectrum disorder, and suggests that we should probably be checking NMO antibody status in more patients with unexplained myelopathy. | |
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Keywords:
AQP4 antibody, Brown - Sequard syndrome, Devic disease, Multiple sclerosis, Spinal cord, Traumatic injury, Neuromyelitis optica
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Author Contributions
Abhinav Agrawal – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published Dennis Lourdusamy – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published Abhishek Agarwal – Substantial contributions to conception and design, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published Neil R. Holland – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published |
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Guarantor of submission
The corresponding author is the guarantor of submission. |
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Source of support
None |
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Conflict of interest
Authors declare no conflict of interest. |
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Copyright
© 2015 Abhinav Agrawal et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information. |
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About The Authors
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